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  • Title: A prospective study of waist circumference and body mass index in relation to colorectal cancer incidence.
    Author: Wang Y, Jacobs EJ, Patel AV, Rodríguez C, McCullough ML, Thun MJ, Calle EE.
    Journal: Cancer Causes Control; 2008 Sep; 19(7):783-92. PubMed ID: 18322811.
    Abstract:
    OBJECTIVES: To study the association between waist circumference and colorectal cancer, and whether it is independent of body mass index (BMI). METHODS: Between 1997 and 2005, 953 incident colorectal cancer cases (546 men and 407 women) were identified among 95,151 participants (44,068 men and 51,083 women) from the Cancer Prevention Study-II Nutrition Cohort. RESULTS: Waist circumference was associated with increased colorectal cancer incidence in both men (multivariable adjusted rate ratio (RR) 1.68, 95% confidence interval (CI) 1.12-2.53 for waist circumference > or =120 cm compared to <95 cm, p trend = 0.006) and women (RR 1.75, 95% CI 1.20-2.54 for > or =110 compared to <85 cm, p trend = 0.003). High levels of BMI were also associated with increased risk. After adjustment for BMI, waist circumference remained associated with a nonstatistically significant increase in colorectal cancer incidence in both men (RR 1.41, 95% CI 0.81-2.45 for > or =120 compared to <95 cm, p trend = 0.10) and women (RR 1.48, 95% CI 0.89-2.48 for > or =110 compared to <85 cm, p trend = 0.13). CONCLUSIONS: Our results confirm that waist circumference is associated with increased colorectal cancer incidence, possibly partially independent of BMI.
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