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  • Title: [Preparation of alpha-hydrocycholic-beta-cyclodextrin inclusion compound].
    Author: Bian YH, Zhang DY, Xiong QP.
    Journal: Zhong Yao Cai; 2007 Nov; 30(11):1452-5. PubMed ID: 18323220.
    Abstract:
    OBJECTIVE: To study the preparation of alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound. METHODS: It was studied with orthogonal design to analysis three factors of inclusion rate such as the weight ratio between HDCA and beta-Cyclodextrin, the temperature and the reaction time. Fourier transform infrared spectroscopy, scanning electron microscopy, taste and solubility test were used to identify the inclusion compound. RESULTS: Stable inclusion compound was made by HDCA and beta-Cyclodextrin. The weight ratio between HDCA and beta-Cyclodextrin was the most important factor. The alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound taste and the solubility were improved. CONCLUSION: The optimum preparation condition is alpha-Hydrocycholic : beta-Cyclodextrin = 8.67 : 1, the inclusion temperature is 60 degrees C and the inclusion time is 30 minutes.
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