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  • Title: Studies of in vitro megakaryocytopoiesis in adult immune thrombocytopenic purpura (ITP).
    Author: Bellucci S, Han ZC, Caen JP.
    Journal: Eur J Haematol; 1991 Aug; 47(2):86-90. PubMed ID: 1832388.
    Abstract:
    In vitro megakaryocytopoiesis was studied in 8 patients with chronic immune thrombocytopenia (ITP). A significant increase of megakaryocyte (MK) colony formation was observed in 5/5 patients studied. Furthermore, the serum of these 8 patients was able to enhance MK colony formation by normal marrow cells. This effect was neither due to a decrease of inhibitors of megakaryocytopoiesis such as betathromboglobulin (beta TG) nor to the IgG fraction of patients' serum. In addition, the level of interleukin 6, which is above all a stimulus for MK maturation, was found within the normal range in 8/8 patients tested. These data suggest that in chronic ITP there is an increase of MK progenitor cell number which may be due to an increased level of MK colony-stimulating activity.
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