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  • Title: Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
    Author: Kamal A, Shankaraiah N, Prabhakar S, Reddy ChR, Markandeya N, Reddy KL, Devaiah V.
    Journal: Bioorg Med Chem Lett; 2008 Apr 01; 18(7):2434-9. PubMed ID: 18325766.
    Abstract:
    A new class of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-chalcone conjugates have been prepared by employing a solid-phase synthetic protocol. In this strategy an intramolecular aza-Wittig reductive cyclization approach has been utilized. Interestingly, some of these molecules have shown enhanced DNA-binding affinity and promising anticancer activity on a large number of human cancer cell lines.
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