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  • Title: The depth-dependence of the biological effectiveness of 60Co gamma rays in a large absorber determined by dicentric chromosomes in human lymphocytes.
    Author: Schmid E, Roos H, Kramer HM.
    Journal: Radiat Prot Dosimetry; 2008; 130(4):442-6. PubMed ID: 18325932.
    Abstract:
    Radiobiological evidence is shown concerning a significant depth-dependence of the maximum relative biological effectiveness at limiting low doses (RBE(M)) of (60)Co gamma rays in a cubic polymethylmethacrylate (PMMA) phantom of 30 cm edge length. Using the dose-response curve for the dicentric data in human lymphocytes obtained in the present experiment at a depth of 20 cm, together with the comprehensive and consistent data set determined earlier at smaller depths of the PMMA phantom, there is an increase in the RBE(M) value by a factor of 2.18 +/- 1.25 at a depth of 20 cm relative to 1 cm in the phantom. All the dicentric data are based on identical exposure durations and irradiation temperatures as well as identical culture and evaluation conditions, with blood from the same donor.
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