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  • Title: [Primary drug resistance in Mycobacterium tuberculosis among patients with pulmonary tuberculosis and its impact on permanent disability in the Volgograd region].
    Author: Borzenko AS, gagarina SG, Samoĭlova IV, Kalushenina AA.
    Journal: Probl Tuberk Bolezn Legk; 2007; (12):28-30. PubMed ID: 18326212.
    Abstract:
    In the past 5 years, there has been a rise in the number of patients with new-onset drug-resistant pulmonary tuberculosis from 32.3% to 44.0%. The pattern of primary resistance is marked by an increase in the proportion of multidrug resistant Mycobacterium tuberculosis (MBT) strains, by the steady-state level of their isolation, and by a reduction in the detection rate of unidrug resistant strains. The efficiency of treatment in pulmonary tuberculosis patients with primary MBT resistance depends on patient compliance. After 3-year follow-up, death occurred in 12.2% of the patients, the tuberculous process became chronic in 31.7%, and there was a relapse in 9.8%. The drug resistance of the causative agent affects the duration of disability due to tuberculosis to a greater extent than does multidrug resistance.
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