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  • Title: Critical micellar concentrations of keto derivatives of selected bile acids: thermodynamic functions of micelle formation.
    Author: Posa M, Kevresan S, Mikov M, Cirin-Novta V, Kuhajda K.
    Journal: Colloids Surf B Biointerfaces; 2008 Jul 15; 64(2):151-61. PubMed ID: 18328679.
    Abstract:
    The knowledge of the process of formation of molecular aggregates of bile acids in aqueous media and of the corresponding critical micellar concentrations (CMCs) is of great significance because of the biological importance of these compounds and their pharmacological applications. In view of this, the present study is concerned with the determination of CMCs of cholic and chenodeoxycholic acids and their keto derivatives at different temperatures with the aim to calculate the standard thermodynamic functions of micelle formation. Based on the molecular descriptors for tested compounds and entropy of micelle formation, the method of principal component analysis (PCA) allowed grouping of the behavior of tested molecules at 30, 50 and 70 degrees C. To one group belong cholic acid and its keto derivatives, the other group consisting of chenodeoxycholic and deoxycholic acids and their keto derivatives. For each group, the derived multiple linear regression equations of the entropy dependence on temperature contains different independent variables. A main difference between the two groups of tested bile acids is in the energy of dipole-dipole interaction, which appears to be temperature dependent, and in the case of the latter group comes into play as an independent variable already in the regression equation derived for 30 degrees C. The most remarkable changes of the descriptors with temperature were observed in the group of cholic acid and its derivatives.
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