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  • Title: Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China.
    Author: Zhu G, Qu Y, Jin N, Sun Z, Liu T, Lee H, Tian M, Wang T.
    Journal: Infection; 2008 Mar; 36(2):140-6. PubMed ID: 18330507.
    Abstract:
    BACKGROUND: In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations. However, the epidemiological data of HEV infections in Jilin is shortage. METHODS: The seroepidemiological study was conducted by enzyme-linked immunosorbent assay, and the conserved genomic sequences of open reading frame 2 (348 bp) was detected using reverse transcription-PCR. RESULTS: Overall, 1,289 serum samples were positive to HEV-specific immunoglobulin G (IgG), and 180 serum samples were positive to HEV-specific immunoglobulin M (IgM). The seroprevalence of HEV-specific IgG was 26.3%, 27.9%, 25.3%, 32.7% in 2003, 2004, 2005, 2006, respectively. Acute HEV infection mainly occurred in male, people aged from 20 to 69 were more susceptible to infection, and cases with IgM anti-HEV reaction mainly occurred from July to November. HEV RNA was detectable in the serum samples or stool suspension of 15 patients with HEV-specific IgM, and all of these belonged to genotype IV. CONCLUSIONS: Our results indicate that HEV is widely spread in Jilin and confined to genotype IV.
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