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  • Title: Oral subchronic toxicity of a lipid extract from Roystonea regia fruits in mice.
    Author: Gutiérrez A, Gámez R, Mas R, Noa M, Pardo B, Marrero G, Pérez Y, González R, Curveco D, García H.
    Journal: Drug Chem Toxicol; 2008; 31(2):217-28. PubMed ID: 18330783.
    Abstract:
    D-004 is a lipid extract of royal palm (Rosytonea regia) fruits that prevents prostate hyperplasia induced with testosterone in rodents. Previous studies have shown no D-004-related toxicity in rats, but no study in mice had been reported. D-004 (500, 1000, and 2000 mg/kg) was evaluated in a subchronic (eight weeks) study in NMRI mice. No evidences of treatment-related toxicity were detected. Thus, body-weight gain, clinical observations, food consumption, blood biochemical, hematology, organ-weight ratios, and histopathological findings were similar in control and treated groups. This study supports that D-004 orally administered up to 2000 mg/kg did not induce treatment-related toxicity.
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