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  • Title: Encephalopathy with combined lithium-risperidone administration.
    Author: Boora K, Xu J, Hyatt J.
    Journal: Acta Psychiatr Scand; 2008 May; 117(5):394-5; discussion 396. PubMed ID: 18331580.
    Abstract:
    OBJECTIVE: Lithium-neuroleptics induced encephalopathy is a rare drug interaction. Here I am reporting a patient who developed reversible encepatholopathy with lithium-risperidone combination. METHOD: A single case report. RESULT: A patient of bipolar disorder, who presented with manic symptoms with psychotic feature, started with a combination of lithium and risperidone. Within few days, the patient developed encepatholopathy, which reversed upon discontinuation of lithium and risperidone. CONCLUSION: Combining lithium and neuroleptic is useful in treatment of bipolar disorder. However, encepatholapthy can be anticipated to result when lithium is used with high potency anti-psychotic such as haloperidol and risperidone and there are baseline EEG abnormalities.
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