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  • Title: Prolymphocytic leukaemia of B- and T-cell subtype: a state-of-the-art paper.
    Author: Dungarwalla M, Matutes E, Dearden CE.
    Journal: Eur J Haematol; 2008 Jun; 80(6):469-76. PubMed ID: 18331594.
    Abstract:
    Prolymphocytic leukaemias of B and T cell subtype are rare diseases. Despite recent advances in immunophenotyping and molecular cytogenetics, leading to a better understanding of the underlying cell biology of the prolymphocytic leukaemias, prognosis for these patients remains poor. Purine analogues and monoclonal antibodies have shown efficacy in B-cell prolymphocytic leukaemia although further studies are warranted. Monoclonal antibody therapy with alemtuzumab has significantly improved outcome in T-cell prolymphocytic leukaemia (T-PLL) but responses are still transient and further disease progression is inevitable. While allogeneic stem cell transplant is an attractive option, due to the older age group of T-PLL patients the morbidity and mortality associated with the procedure is significant.
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