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  • Title: [Immunogenic properties of a polyvalent inactivated vaccine from respiratory viruses (IBR, Pi-3, Ad-1, Ad-3].
    Author: Khristov S, Karadzhov I, Ignatov G, Khristova V.
    Journal: Vet Med Nauki; 1976; 13(4):36-44. PubMed ID: 183342.
    Abstract:
    Studied was the authors' inactivated polyvalent vaccine having an adjuvant, prepared from the respiratory viruses IBR, Pi-3, Ad-1 and Ad-3. It was found that at the subcutaneous vaccination of calves and pregnant cows there were virus-neutralizing, hemagglutination-inhibition, and complement-fixing antibodies as established by the 14th day following treatment. Revaccination was carried out on the twenty-eighth day when the antibodies reached high titers. The latter showed peak values on the 14th day following revaccination. The prevaccinal and vaccinal antibodies did not interfere with the process of immunogenesis. The virus-neutralizing antibodies against IBR had a titer of 5 log on the 150th day, while the virus-neutralizing and hemagglutination-inhibition antibodies against Pi-3 showed the same titer even after the 180th day following vaccination. There were in the milk of the vaccinated cows, in the seventh month of pregnancy, specific lactoglobulins of the IgA and IgG classes which were contained in the 27-36, 45-48 and 51-54 fractions, distributed in three peaks by their protein content. The level of the virus-neutralizing, hemagglutination-inhibition, and complement-fixing antibodies against the inactivated vaccinal respiratory viruses showed that the subcutaneous treatment with the polyvalent vaccine leads to the production of antibodies that are secreted with milk
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