These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Serum pro-inflammatory cytokines in physiological and pre-eclamptic pregnancies.
    Author: Montagnana M, Lippi G, Albiero A, Salvagno GL, Franchi M, Guidi GC.
    Journal: Gynecol Endocrinol; 2008 Mar; 24(3):113-6. PubMed ID: 18335322.
    Abstract:
    BACKGROUND: Pre-eclampsia is a heterogeneous syndrome ranging from mild hypertension and proteinuria to severe pre-eclampsia with complications, which can also be associated with an enhanced maternal inflammatory response. METHODS: Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) were evaluated by multiplexed sandwich enzyme-linked immunosorbent assay in 14 pre-eclamptic women, 57 normotensive pregnant women (20 in the first, 20 in the second and 17 in the third trimester) and 21 non-pregnant women. RESULTS: The concentration of serum TNF-alpha was lower than the sensitivity limit of the assay in all groups. The prevalence of measurable IL-1 and IL-6 values, but not that of IFN-gamma, increased significantly in the second and third trimesters of pregnancy. However, the percentage of subjects with higher or detectable values of pro-inflammatory cytokines was statistically different between pre-eclamptic women and those in the second and third trimester of physiological pregnancy. CONCLUSIONS: Results of this study do not support standard screening for pro-inflammatory cytokines (TNF-alpha, IL-1, IL-6 and IFN-gamma) in pre-eclampsia.
    [Abstract] [Full Text] [Related] [New Search]