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  • Title: Complexation of L-lactate with boronic acids: a solution and holographic analysis.
    Author: Sartain FK, Yang X, Lowe CR.
    Journal: Chemistry; 2008; 14(13):4060-7. PubMed ID: 18335445.
    Abstract:
    Boronic acids have been used as receptors for the detection of diols and alpha-hydroxy acids. The incorporation of 3-acrylamide phenyl boronic acid (3-APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L-lactate. However, it was also found that the use of 3-APB resulted in the sensor being responsive towards a number of other compounds containing two hydroxy groups. This report details the further investigation into the reaction between L-lactate and three boronic acid-based receptors, both in the holograms and in solution, in order to establish the mechanism of binding. A novel boronate receptor is proposed based on this understanding.
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