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  • Title: A dearomatizing, thionium ion cyclization for the synthesis of functionalized, azaspirocyclic cyclohexadienones.
    Author: Ovens C, Martin NG, Procter DJ.
    Journal: Org Lett; 2008 Apr 03; 10(7):1441-4. PubMed ID: 18335948.
    Abstract:
    Thionium ions, generated by the addition of thiols to N-benzylglyoxamides, undergo a dearomatizing spirocyclization. The alkyl or arylsulfanyl group introduced during the thionium ion cyclization can act as a synthetic handle and a stereochemical control element during modifications of the azaspirocyclic frameworks (R(F) = CH(2)CH(2)C(8)F(17)).
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