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  • Title: A novel cholic acid-based contrast enhancement agent for targeted MRI.
    Author: Chong HS, Song HA, Lim S, Macrenaris K, Ma X, Lee H, Bui P, Meade T.
    Journal: Bioorg Med Chem Lett; 2008 Apr 01; 18(7):2505-8. PubMed ID: 18337094.
    Abstract:
    The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.
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