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  • Title: Prognostic factors for hypopharyngeal cancer: a univariate and multivariate study of 142 cases.
    Author: Mochiki M, Sugasawa M, Nibu K, Asai M, Nakao K, Asakage T.
    Journal: Acta Otolaryngol Suppl; 2007 Dec; (559):136-44. PubMed ID: 18340585.
    Abstract:
    CONCLUSIONS: Reduction of distant metastases is essential for better survival. Effective adjuvant chemotherapy should be developed for patients with advanced primary disease (T>2) as well as for patients with advanced nodal status (N>0 or PLN>2). OBJECTIVES: The aim of this study was to identify prognostic factors for hypopharyngeal cancer. PATIENTS AND METHODS: In all, 142 previously untreated patients were analyzed retrospectively; 75% of the cases were stage III or IV. Surgical resection was administered as primary treatment to 116 of the patients (82%), while 26 patients (18%) underwent primary radiotherapy. RESULTS: The cause-specific 5-year actuarial survival was 46.3%. Distant metastases were the most frequent (23%) cause of failure, followed by local recurrence (15%), and regional recurrence (13%). Cox's regression analysis showed that the significant factors affecting cause-specific survival were N classification, T classification, number of pathological lymph node metastases (PLN), lymphatic invasion, and positive surgical margin. Similarly, T classification and PLN affected distant metastases.
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