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  • Title: Beta-thromboglobulin and polymorphonuclear leukocytes activation. (Effects on chemiluminescence, release of membrane bound calcium, NADPH-oxidase activity and membrane fluidity).
    Author: Allegrezza-Giulietti A, Serretti R, Beccerica E, Ferretti G, Cervini C.
    Journal: Biochem Int; 1991 May; 24(2):273-9. PubMed ID: 1834061.
    Abstract:
    The aim of this paper was to evaluate the "in vitro" interaction between beta-thromboglobulin, one specific platelet release product and polymorphonuclear leukocytes. The effects of beta-thromboglobulin were tested on the following features of polymorphonuclear leukocytes activation: opsonized zymosan and phorbol myristate acetate stimulated chemiluminescence, release of membrane bound calcium, NADPH-oxidase activity, and membrane fluidity. Beta-thromboglobulin caused a decrease of the chemiluminescent response of polymorphonuclear leukocytes, using both agonists, with and without preincubation with polymorphonuclear leukocytes. We observed that beta-thromboglobulin caused a decrease also in the activity of NADPH-oxidase but not in the release of membrane bound calcium. Moreover beta-thromboglobulin caused a decrease of the polymorphonuclear leukocytes membrane fluidity. Our results suggest that the beta-thromboglobulin could play a role in the reciprocal interactions between platelets and polymorphonuclear leukocytes.
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