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  • Title: The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions.
    Author: Tomasi T, Hakeda-Suzuki S, Ohler S, Schleiffer A, Suzuki T.
    Journal: Neuron; 2008 Mar 13; 57(5):691-704. PubMed ID: 18341990.
    Abstract:
    During Drosophila visual system development, photoreceptor (R) axons choose their correct paths and targets in a step-wise fashion. R axons with different identities make specific pathfinding decisions at different stages during development. We show here that the transmembrane protein Golden goal (Gogo), which is dynamically expressed in all R neurons and localizes predominantly to growth cones, is required in two distinct steps of R8 photoreceptor axon pathfinding: Gogo regulates axon-axon interactions and axon-target interactions in R8 photoreceptor axons. gogo loss-of-function and gain-of-function phenotypes suggest that Gogo mediates repulsive axon-axon interaction between R8 axons to maintain their proper spacing, and it promotes axon-target recognition at the temporary layer to enable R8 axons to enter their correct target columns in the medulla. From detailed structure-function experiments, we propose that Gogo functions as a receptor that binds an unidentified ligand through its conserved extracellular domain.
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