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  • Title: Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.
    Author: Periyasami G, Raghunathan R, Surendiran G, Mathivanan N.
    Journal: Bioorg Med Chem Lett; 2008 Apr 01; 18(7):2342-5. PubMed ID: 18342506.
    Abstract:
    A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities.
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