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  • Title: Pathophysiology of myocardial infarction: protection by ischemic pre- and postconditioning.
    Author: Skyschally A, Schulz R, Heusch G.
    Journal: Herz; 2008 Mar; 33(2):88-100. PubMed ID: 18344027.
    Abstract:
    One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments, a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre- and postconditioning in patients with coronary artery disease.
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