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  • Title: Demonstration of a pituitary gonadotrophin hormone activity in the male foetal mouse.
    Author: Pointis G, Mahoudeau JA.
    Journal: Acta Endocrinol (Copenh); 1976 Sep; 83(1):158-65. PubMed ID: 183442.
    Abstract:
    The testosterone production by 18-days-old foetal mouse testis was measured in an organ culture system, by RIA in the culture medium. This production was time-dependent, and could be stimulated by ovine LH and age-matched foetal pituitary. The gonadotrophin activity derived from foetal pituitary appeared to be released into the culture medium as a limited reserve. These data clearly show that a biologically active gonadotrophin material is present in the pituitary of the 18-days-old mouse foetus.
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