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  • Title: IgG anti-IgE autoantibodies in immunoregulation.
    Author: Stadler BM, Gang Q, Vogel M, Jarolim E, Miescher S, Aebischer I, de Weck AL.
    Journal: Int Arch Allergy Appl Immunol; 1991; 94(1-4):83-6. PubMed ID: 1834585.
    Abstract:
    Human sera contain anti-IgE autoantibodies with diverse biological functions in vitro. Opposite functions can be shown for triggering of IgE-mediated histamine release from human basophils in terms of anaphylactogenic or nonanaphylactogenic autoantibodies. Furthermore, autoantibodies are either capable of removing IgE from the surface of CD23-positive cells of binding more IgE to such cells. A similar dichotomy seems also to exist for the effect of autoantibodies on human IgE mRNA synthesis as well as IL-4-induced proliferation of human mononuclear cells. Thus, anti-IgE autoantibodies may represent a key factor in the manifestation and the development of allergic disease.
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