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  • Title: Comparison of the cardiovascular effects of isoflurane and sevoflurane as measured by magnetic resonance imaging in children with congenital heart disease.
    Author: Dalal PG, Corner A, Chin C, Wood C, Razavi R.
    Journal: J Clin Anesth; 2008 Feb; 20(1):40-4. PubMed ID: 18346608.
    Abstract:
    STUDY OBJECTIVE: To compare the cardiovascular effects of isoflurane and sevoflurane at minimum alveolar concentration (MAC) = 1 in children with congenital heart disease using cardiac magnetic resonance imaging. DESIGN: Randomized, crossover, single-blinded study. SETTING: Tertiary-care teaching hospital. PATIENTS: 10 pediatric patients with congenital heart diseases scheduled to undergo cardiac magnetic resonance studies. INTERVENTIONS: Patients were randomized to receive either isoflurane or sevoflurane as the "first inhalation agent." After a period or more than 20 minutes, they were crossed over to receive the "second inhalation agent." MEASUREMENTS: Heart rate, mean arterial pressure (MAP), cardiac index, stroke volume index, and ejection fraction (EF) at one MAC for both agents were all recorded. MAIN RESULTS: Both isoflurane and sevoflurane caused a significant decrease in MAP from the baseline (P = 0.013). The mean values (+/-SD) of stroke volume (mL), cardiac index (L min(-1) m(-2)), and EF (%) for isoflurane versus sevoflurane were 21.5 (+/-9.2) versus 19.6 (+/-6.2), 4.1 (+/-1.2) versus 3.7 (+/-0.87), and 64.2 (+/-14.5) versus 62.5 (+/-13.8), respectively. CONCLUSION: Both isoflurane and sevoflurane were found to be comparable in terms of cardiovascular effects.
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