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  • Title: Wrestling off RAD51: a novel role for RecQ helicases.
    Author: Wu L.
    Journal: Bioessays; 2008 Apr; 30(4):291-5. PubMed ID: 18348153.
    Abstract:
    Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks and damaged replication forks. However, inappropriate or aberrant HR can also result in genome rearrangements. The maintenance of cell viability is, therefore, a careful balancing act between the benefits of HR (the error-free repair of DNA strand breaks) and the potential detrimental outcomes of HR (chromosomal rearrangements). Two papers have recently provided a mechanistic insight into how HR may be tempered by RecQ helicases to prevent genome instability and diseases that are a consequence of this, such as cancer.
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