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  • Title: Do different vaccination regimens for BCG and hepatitis B affect the development of allergic disorders in early childhood?
    Author: Dilli D, Bostanci I, Dallar Y.
    Journal: J Asthma; 2008 Mar; 45(2):155-9. PubMed ID: 18350408.
    Abstract:
    AIM: To determine whether age at bacilli Calmette-Guérin (BCG) and hepatitis B vaccination has an effect on the development of atopy and allergic disorders in early childhood. METHODS: This was a cross-sectional study of 109 children aged between 24 and 36 months with respiratory system diseases. The study population was divided into two groups according to vaccination regimens: group 1, beginning hepatitis B vaccination at birth and receiving BCG vaccine at two months of age; group 2, receiving BCG vaccine at birth and beginning hepatitis B vaccination at two months of age. Atopic status was assessed by skin-prick tests (SPTs). RESULTS: There was no statistically significant difference in atopy between two groups (p = 0.27). However, the prevalence of recurrent wheezing was higher in group 1 (36.4%) than group 2 (16.3%) (p = 0.04). Logistic regression analysis identified receiving BCG vaccine at birth and beginning hepatitis B vaccination at the age of two months were protective for recurrent wheezing (odds ratio 0.5; confidence interval: 0.3-0.8; p = 0.01). CONCLUSION: We believe that the administration of BCG vaccine at birth and hepatitis B vaccine at two months may be protective against recurrent wheezing but doesn't prevent atopy.
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