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  • Title: Anticholinergic bronchodilators for adult obstructive airways disease.
    Author: Chapman KR.
    Journal: Am J Med; 1991 Oct 21; 91(4A):13S-16S. PubMed ID: 1835290.
    Abstract:
    Quaternary anticholinergic bronchodilators offer gradual and sustained bronchodilation to patients who have asthma or chronic obstructive pulmonary disease. For asthma, the anticholinergic compounds are less potent than the beta-adrenergic agents but have useful additive bronchodilator properties when combined with beta-adrenergic agents or theophylline. They may be particularly useful in combination regimens for patients who have severe asthma and for older asthmatics. The rationale for such a combination is most compelling in the treatment of acute exacerbations of asthma. For chronic obstructive pulmonary disease, anticholinergic compounds offer greater bronchodilation than beta-adrenergic agents for most patients and are thus considered useful initial therapy in maintenance regimens.
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