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  • Title: Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
    Author: Lee J, Choi H, Kim KH, Jeong S, Park JW, Baek CS, Lee SH.
    Journal: Bioorg Med Chem Lett; 2008 Apr 01; 18(7):2292-5. PubMed ID: 18353638.
    Abstract:
    A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
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