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  • Title: Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum.
    Author: Ayouba A, Badaut C, Kfutwah A, Cannou C, Juillerat A, Gangnard S, Behr C, Mercereau-Puijalon O, Bentley GA, Barré-Sinoussi F, Menu E.
    Journal: AIDS; 2008 Mar 30; 22(6):785-7. PubMed ID: 18356610.
    Abstract:
    Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.
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