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  • Title: Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice.
    Author: Lalonde R, Strazielle C.
    Journal: J Neurosci Methods; 2008 Jun 15; 171(1):48-52. PubMed ID: 18358538.
    Abstract:
    The relations between open-field, elevated plus-maze, and emergence tests were examined in two strains of mice. In the open-field, C57BL/6J mice had more ambulatory movements and rears but not stereotyped movements relative to BALB/c. In addition, C57BL/6J mice entered more often than BALB/c into enclosed and open arms of the elevated plus-maze. When placed inside a large enclosure, C57BL/6J mice emerged more quickly than BALB/c from a small toy object. In the entire series of mice, ambulation and rears in the open-field were linearly correlated with open and enclosed arm visits in the elevated plus-maze. Ambulatory movements and rears were also correlated with emergence latencies. In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests.
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