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  • Title: Effects of pair-housing after social defeat experience on elevated plus-maze behavior in rats.
    Author: Nakayasu T, Ishii K.
    Journal: Behav Processes; 2008 Jul; 78(3):477-80. PubMed ID: 18358638.
    Abstract:
    Social defeat experience in male rats causes an increase in anxiety-like behavior in the elevated plus-maze. Some researchers have suggested that housing rats socially following social defeat attenuates and/or prevents an increase in anxiety-like behavior. However, many other studies have shown that individual housing per se enhances anxiety-like behavior even in the absence of social defeat. In the present study, we assessed the relative contributions of the experience of social defeat and housing conditions on animals' performance in the elevated plus-maze. Rats were assigned to one of the following four groups: defeat/individual housing, defeat/pair-housing, non-defeat/individual housing, and non-defeat/pair-housing. The elevated plus-maze test was conducted 2 weeks after the defeat experience. Our results demonstrated that the defeat/individual housing group spent less time than the other groups in the open arms: moreover, there were no differences between the other three groups. These results confirm the claim that the group-housing of rats prevents an increase in anxiety-like behavior caused by defeat.
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