These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties.
    Author: Cena C, Chegaev K, Balbo S, Lazzarato L, Rolando B, Giorgis M, Marini E, Fruttero R, Gasco A.
    Journal: Bioorg Med Chem; 2008 May 01; 16(9):5199-206. PubMed ID: 18359636.
    Abstract:
    In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3-OH (4a-f) or 2-OH group (7a-c) of ascorbic acid (ASA). Log Ps and pK(a)s of these products were experimentally evaluated. All the compounds were tested for their antioxidant activity on lipidic peroxidation induced by Fe(3+)-ADP/NADPH in lipids of microsomal membranes of rat hepatocytes. Only 3-O series displays antioxidant activity and it seems to be principally dependent on the lipophilicity. Both series trigger in vitro NO-dependent vasodilator properties.
    [Abstract] [Full Text] [Related] [New Search]