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  • Title: [Correlation of aquaporin 1 with hypoxia-inducible factor 1 in breast cancer].
    Author: Yin TJ, Yu SY, Xiao L, Zhang J, Liu C, Lu YP, Liu CP.
    Journal: Zhonghua Yi Xue Za Zhi; 2008 Jan 22; 88(4):258-60. PubMed ID: 18361838.
    Abstract:
    OBJECTIVE: To determinate the correlation of aquaporin 1 (AQP1) and hypoxia-inducible 1 (HIF-1). METHODS: 155 samples of breast cancer obtained during radical mastectomy underwent immunohistochemistry to detect the expression of AQP1 and HIF-1. RESULTS: The positive rates of AQP1 in the HIF1 positive group was 297 +/- 25, significantly higher than that of HIF1 negative group (168 +/- 38, P < 0.001). CONCLUSION: AQP1 is positively correlated with HIF1. The interaction of AQP1 and HIF1 may co-regulate the progress of breast cancer.
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