These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].
    Author: Guxens M, Tomás M, Elosua R, Aldasoro E, Segura A, Fiol M, Sala J, Vila J, Fullana M, Sentí M, Vega G, de la Rica M, Marrugat J, investigadores del estudio IBERICA.
    Journal: Rev Esp Cardiol; 2008 Mar; 61(3):269-75. PubMed ID: 18361900.
    Abstract:
    INTRODUCTION AND OBJECTIVES: Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and PON2-311 polymorphisms and their interaction on AMI risk. METHODS: This case-control study involved 746 consecutive AMI patients and 1796 control subjects without cardiovascular disease, who were randomly selected from the same population from which the patients came. All participants were recruited between 1999 and 2000 from four Spanish autonomous regions. All were assessed for the presence of PON1-192 and PON2-311 and for classical cardiovascular risk factors. Multivariate analysis was carried out using logistic regression modeling. RESULTS: The odds ratios (OR) of AMI for patients with the PON1-192 QQ and PON2-311 SS genotypes (who comprised 50% and 66% of the population, respectively) were 1.26 (95% confidence interval [CI], 1.02-1.55) and 1.25 (95% CI, 1.04-1.50), respectively, compared with R and C allele carriers. Moreover, in patients with both QQ and SS genotypes, the adjusted OR of AMI increased to 1.41 (95% CI, 1.13-1.76). CONCLUSIONS: Our results indicate that the PON1-192 and PON2-311 polymorphisms were independent risk factors of AMI in our population.
    [Abstract] [Full Text] [Related] [New Search]