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  • Title: Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate.
    Author: Shenoy RD, Bhat KG, Kamath N, Kumble Y.
    Journal: Pediatr Hematol Oncol; 2008 Mar; 25(2):123-9. PubMed ID: 18363179.
    Abstract:
    Transient myeloproliferative disorder seen in neonates with Down syndrome is often thought to have a benign course. The authors describe the clinical and laboratory profile of a neonate with Down phenotype and transient myeloproliferative disorder with pericardial effusion as co-morbidity. Pericardial fluid analysis showed eosinophils. Pericardial effusion resolved with prednisolone therapy. Regression in hepatosplenomegaly with clearance of blasts was seen by third week of illness. The clinical course suggested a benign infiltration of the pericardium. Presence of eosinophils supports the differentiating capability of the blast cells in transient myeloproliferative disorders.
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