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Title: Invasive pulmonary aspergillosis after liver transplantation: rapid and complete response to combined and sequential antifungal therapy. Author: Can MF, Yagci G, Gorenek L, Tozkoparan E, Ozerhan I, Cetiner S. Journal: Surg Infect (Larchmt); 2008 Feb; 9(1):99-104. PubMed ID: 18363474. Abstract: BACKGROUND: Invasive pulmonary aspergillosis is a rare, but severe and potentially fatal, complication after liver transplantation. There is no therapeutic regimen accepted worldwide for both initial and continuation therapy; nevertheless, several options have been proposed. METHODS: Case report and review of the pertinent English-language literature. RESULTS: In a patient with pulmonary aspergillosis after a liver transplant, combined and sequential therapy with caspofungin and voriconazole with termination of the immunosuppressive regimen and careful management were helpful to control the infection rapidly, possibly because of a positive drug interaction. CONCLUSION: In cases of invasive aspergillosis that are refractory to monotherapy, this regimen may be used in an attempt to overcome the infection.[Abstract] [Full Text] [Related] [New Search]