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  • Title: [Post-translational regulation of N-glycosylated proteins expression in human intestinal cells in culture].
    Author: Ogier-Denis E, Sapin C, Bauvy C, Hourri JJ, Aubery M, Trugnan G, Codogno P.
    Journal: C R Seances Soc Biol Fil; 1991; 185(4):182-9. PubMed ID: 1836412.
    Abstract:
    HT-29 cells derived from a human colonic adenocarcinoma, can express a typical intestinal differentiation. Undifferentiated HT-29 cells accumulate N-linked glycoproteins substituted with unprocessed carbohydrate chains before to degrade them. Conversely, carbohydrate chains of N-linked glycoproteins are classically processed in differentiated HT-29 cells. The instability of N-linked glycoproteins in undifferentiated HT-29 cells is due to their rapid delivery from the endoplasmic reticulum to a compartment with lysosomal characteristics. This catabolitic pathway involves a bypass of the Golgi apparatus.
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