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  • Title: The short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence.
    Author: Pinto E, Reggers J, Gorwood P, Boni C, Scantamburlo G, Pitchot W, Ansseau M.
    Journal: Alcohol Alcohol; 2008; 43(4):398-400. PubMed ID: 18364363.
    Abstract:
    AIMS: The short (S) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR) contributes to the risk of alcohol dependence and co-occurring clinical features. We studied the putative link between this allele and relapse. METHODS: 48 alcohol-dependent male patients were recruited and genotyped for the 5-HTTLPR. Relapse to alcohol drinking was monitored during 3 months after standardized withdrawal. RESULTS: The S allele was significantly associated with relapse (p = 0.008) while no other factor that was measured played a significant role. CONCLUSIONS: The S allele of the 5-HTTLPR polymorphism may influence the risk of relapse in abstinent alcohol-dependent patients, possibly through intermediate phenotypes.
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