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  • Title: [Strophanthin induced changes in the ion currents of Lymnaea stagnalis and Planorbis corneus neurons].
    Author: Ignatov IuD, Vislobokov AI, Borisova VA.
    Journal: Eksp Klin Farmakol; 2008; 71(1):8-11. PubMed ID: 18365479.
    Abstract:
    Experiments on isolated neurons of Lymnaea stagnalis and Planorbis corneus using the intracellular dialysis and fixed membrane potential techniques showed that strophanthin G in a concentration range from 10(-11) to 10(-6) M produce dolse-dependent reversible suppression of the ion currents in potassium, calcium, and sodium channels. At the maximum concentration (10(-6) M), the maximum suppression (up to 55% of that in the control) was observed for the calcium ion current. At the minimum concentration (10(-12) M), the drug did not influence the sodium ion current, but slightly (approximately by 5%) increased the calcium and potassium ion currents. In addition, strophanthin accelerated the inactivation of slow potassium ion currents.
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