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  • Title: [The protein C system in chronic hepatic diseases, and anti-viral therapy].
    Author: Koroĭ PV.
    Journal: Klin Med (Mosk); 2008; 86(2):63-6. PubMed ID: 18368797.
    Abstract:
    The purpose of the investigation was to study the condition of the protein C system in chronic virial hepatitis (CVH) and viral hepatic cirrhosis (HC) during the course of antiviral therapy. The total protein C system activity (in a form of normalized ratio - NR) was studied before and 6 month after antiviral therapy in 27 patients with CVH B, in 79 patients with CVH C, and in 5 patients CVH D, as well in 29 patients with viral HC and 29 patients with alcoholic HC/. The total protein C system activity was decreased in chronic viral hepatic disease, and was minimal in patients with HC; the most severe disturbances were observed in patients with poor prognosis of HC and decompensated portal hypertension. The study found a correlation between NR values and histological manifestation of the pathology, which demonstrates an important role of the protein C system in the progress of chronic hepatic diseases. Anti-virial drugs had a positive effect of the functioning of the protein C system, which may be one of the ways of the realization of their antifibrotic effect.
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