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  • Title: [Efficiency of using ondansetron in the surgical treatment of post-burn cicatricial deformity in children with a history of postoperative nausea and vomiting].
    Author: Lekmanov AU, Tkachenko BA, Suvorov SG.
    Journal: Anesteziol Reanimatol; 2008; (1):21-3. PubMed ID: 18368834.
    Abstract:
    The efficiency of using various formulations of the antiemetic ondansetron to prevent postoperative nausea and vomiting (PONV) in the surgical treatment of postburn scars and deformities in children with a family history of PONV was compared. The patients were randomized into 4 representative groups. Preoperative administration of ondansetron (zofran) as lingual tablets was shown to be most effective. When the drug was used as syrup, PONV developed 2 times more frequently (PONV in 20% of the patients and 3 times more commonly when the drug was intravenously injected as jets during induction to anesthesia (PONV in 30% of the patients. When antiemetics were not given (a control group), the incidence was 7.5 times greater (75% of cases).
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