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  • Title: Principles of Dicer substrate (D-siRNA) design and function.
    Author: Amarzguioui M, Rossi JJ.
    Journal: Methods Mol Biol; 2008; 442():3-10. PubMed ID: 18369774.
    Abstract:
    An efficient RNAi largely depends on optimal design of the siRNA. In recent studies, Dicer substrates were found to be more potent than classical synthetic 21-mer siRNAs, suggesting a coupling of the Dicer-mediated processing step to the efficient assembly of the silencing complex, RISC. We describe the fundamental principles and experimental results leading to optimal Dicer substrates.
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