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  • Title: [The European experience of liver-kidney transplantation for primary hyperoxaluria type I. Prevention of recurrent intrarenal oxalate deposits].
    Author: Lloveras JJ, Dupré-Goudable C, Rey JP, Sporer P, Durand D, Ton That H, Suc JM.
    Journal: Presse Med; 1991 Nov 27; 20(40):2016-8. PubMed ID: 1837115.
    Abstract:
    Following simultaneous liver-kidney transplantation for primary hyperoxaluria type I, although the missing enzyme is provided by the liver transplant, there is a risk of recurrent calcium oxalate crystal formation in the implanted kidney. The necessary kidney protection methods are extrarenal blood purification, principally haemodialysis and haemofiltration, and an abundant diuresis ensured by copious fluid intakes together with prescription of diuretics. These therapeutic measures reduce the oxalate concentrations in both blood and urine. Oxalates are excreted in large amounts over a long period, owing to the formation of important tissue deposits during systemic oxalosis.
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