These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C.
    Author: Hoelting T, Duh QY, Clark OH, Herfarth C.
    Journal: Cancer Lett; 1997 Oct 28; 119(1):1-5. PubMed ID: 18372514.
    Abstract:
    Signal transduction of a human follicular thyroid cancer cell line (FTC133) was investigated. The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%. TSH and EGF stimulated invasion of FTC133. Antagonism of PKC reversed TSH-mediated stimulation, whereas it had no effect on EGF-stimulation. Our data provide evidence for an essential role of PKC in signal transduction of invasive thyroid cancer.
    [Abstract] [Full Text] [Related] [New Search]