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  • Title: Novel anticoagulant peptides from the functional site of human placental anticoagulant protein.
    Author: Funakoshi T, Abe M, Sakata M, Shoji S, Kubota Y, Shimada H, Kojima S.
    Journal: Biochem Int; 1991 May; 24(1):173-80. PubMed ID: 1837452.
    Abstract:
    Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. However, the peptide KHALKG, corresponding to the region from Lys-97 to Gly-102, did not exhibit an anticoagulant activity, showing that it is not included in the functional site. These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not.
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