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  • Title: Remission of infantile generalized myofibromatosis after interferon alpha therapy.
    Author: Auriti C, Kieran MW, Deb G, Devito R, Pasquini L, Danhaive O.
    Journal: J Pediatr Hematol Oncol; 2008 Feb; 30(2):179-81. PubMed ID: 18376275.
    Abstract:
    Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
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