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  • Title: Mixed-mode oscillations in a three time-scale model for the dopaminergic neuron.
    Author: Krupa M, Popović N, Kopell N, Rotstein HG.
    Journal: Chaos; 2008 Mar; 18(1):015106. PubMed ID: 18377087.
    Abstract:
    Mixed-mode dynamics is a complex type of dynamical behavior that has been observed both numerically and experimentally in numerous prototypical systems in the natural sciences. The compartmental Wilson-Callaway model for the dopaminergic neuron is an example of a system that exhibits a wide variety of mixed-mode patterns upon variation of a control parameter. One characteristic feature of this system is the presence of multiple time scales. In this article, we study the Wilson-Callaway model from a geometric point of view. We show that the observed mixed-mode dynamics is caused by a slowly varying canard structure. By appropriately transforming the model equations, we reduce them to an underlying three-dimensional canonical form that can be analyzed via a slight adaptation of the approach developed by M. Krupa, N. Popovic, and N. Kopell (unpublished).
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