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  • Title: CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
    Author: Wray BN, Stankovich J, Whittock L, Dwyer T, Ponsonby AL, van der Mei IA, Taylor B, Dickinson J, Foote S, McMorran BJ.
    Journal: J Neuroimmunol; 2008 May 30; 196(1-2):139-42. PubMed ID: 18378005.
    Abstract:
    Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
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