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  • Title: Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment.
    Author: Cleary JD, Garcia-Effron G, Chapman SW, Perlin DS.
    Journal: Antimicrob Agents Chemother; 2008 Jun; 52(6):2263-5. PubMed ID: 18378714.
    Abstract:
    We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.
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