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  • Title: Antilipidemic drugs. Part 6: LF 178 in man. A preliminary note on a multicenter investigation bearing on 393 subjects with pure or mixed forms of hyperlipidemia.
    Author: Wülfert B, Majoie B, de Ceaurriz A.
    Journal: Arzneimittelforschung; 1976; 26(5):906-9. PubMed ID: 183789.
    Abstract:
    A total of 393 patients affected by different foms of hyperlipoproteinemia have been treated for up to 12 months or more with a daily dose of 200-400 mg of isopropyl-4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF 178; procetofene; Lipanthyl). In pure hypercholesterolemia (IIa) the mean depression of cholesterol exceeded 26% and the drug induced degree of normalization was 85%. In mixed hypercholesterolemia (IIa) cholesterol was depressed by 23% and triglycerides by approximately 40%. In major affections of hypercholesterolemia (cholesterol > 3.5 gll) the mean induced depression exceeded 30%. Pure hypertriglyceridemia (IV) was strongly affected by the drug LF 178 induced a mean depression of triglycerides exceeding 60% after 6 months of treatment. In all cases the antilipidemic effect was fast and well sustained...
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